Why does the body regain weight so quickly after stopping medication?  Weight returns quickly because the drug’s effects on appetite disappear, and because obesity is a chronic condition that tends to relapse when treatment is interrupted.   This regain is driven by a mix of physiological, behavioural and disease-related factors:  Return of appetite: GLP-1 receptor agonists (such as semaglutide and liraglutide) reduce appetite and help people feel full sooner. When the medication stops, this effect disappears and hunger returns. Experts describe stopping […]

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(SACRAMENTO) This week, the White House announced a deal with Eli Lilly and Novo Nordisk to lower the cost of their GLP-1 weight loss drugs, Wegovy and Zepbound. The move could significantly expand access to these treatments for people with diabetes and obesity. GLP-1 receptor agonists (RA), such as Ozempic and Mounjaro, were initially designed to help manage blood sugar in type 2 diabetes. Now, they are reshaping the landscape of obesity treatment and metabolic health with impacts […]

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About one in eight adults (12%) say that they are currently taking a GLP-1 drug such as Ozempic or Wegovy either to lose weight or treat a chronic condition, an increase from 18 months ago, though the high costs of the medications remain a concern, a new KFF Health Tracking Poll finds. Overall nearly one in five adults (18%) say at some point they have taken a GLP-1 drug, a class of medications used for weight loss […]

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Paccou, J. & Compston, J. E. Bone health in adults with obesity before and after interventions to promote weight loss. Lancet Diabetes Endocrinol. 12, 748–760 (2024). Article  PubMed  Google Scholar  Beavers, K. M. et al. Effect of exercise modality during weight loss on bone health in older adults with obesity and cardiovascular disease or metabolic syndrome: a randomized controlled trial. J. Bone Miner. Res. 33, 2140–2149 (2018). Article  PubMed  Google Scholar  Armamento-Villareal, R. et al. Changes in […]

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Average regain is 0.4kg/month and all weight lost likely to be regained in under 2 yearsWeight regain faster after stopping weight loss drugs than after dietary weight loss programmes Stopping weight loss drugs is followed by weight regain and reversal of beneficial effects on heart and metabolic health markers such as high cholesterol and high blood pressure, finds a study published by The BMJ today. It shows that the average rate of weight regain is 0.4kg/month after stopping treatment, […]

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GLP-1 drugs have ushered in a new era in weight loss. In just a few years, medications such as semaglutide and tirzepatide, known by the brand names Ozempic, Wegovy, Mounjaro and Zepbound, have gone from niche diabetes treatments to household names, reshaping how America thinks about weight loss. A November 2025 Kaiser Family Foundation poll found that 1 in 8 U.S. adults have tried a GLP-1 medication for weight loss, diabetes or another condition. And we expect […]

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Camryn Manheim looked unrecognizable as she showed off her dramatic weight loss. The Emmy-winning actress flaunted her slim figure at the opening night of Rosie O’Donnell’s one-woman show “Common Knowledge” in New York City last week. For the outing, Manheim wore a patterned blouse, jeans and beaded jewelry. Camryn Manheim looked unrecognizable as she showed off her weight loss transformation. Bruce Glikas/WireImage The actress flaunted her slim figure at the opening night of Rosie O’Donnell’s one-woman show Common Knowledge […]

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Any licensed health care provider—including primary care physicians, nurse practitioners, physician assistants, and specialists such as endocrinologists, cardiologists, and gastroenterologists—can prescribe GLP-1 medications. Ideally, the prescriber is someone you can work with long term, says John Morton, MD, MPH, chief of Bariatric and Minimally Invasive Surgery at Yale Medicine and a board-certified obesity medicine specialist. “That’s because obesity is a chronic disease,” Dr. Morton says. “It didn’t happen overnight and it’s not going to get better overnight. […]

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