A daily pill could help people keep weight off and stop them needing other long-term medications, scientists behind landmark new trial data have suggested. The researchers said orforglipron could help prevent more than 200 diseases associated with obesity and could be prescribed to prevent lower levels of overweight tipping into obesity. A large-scale randomised controlled trial found that patients using injectable GLP1s could maintain most of their weight loss if they switched to far cheaper daily pills. […]

An estimated one in eight American adults are taking GLP-1 (glucagonlike peptide 1) drugs including Wegovy and Zepbound to treat conditions such as diabetes or to lose weight. Some experts believe that some people will need to take these medications for life to retain their results. But research suggests most of these individuals will quit the drugs—and when people do so, most of their weight tends to come back. The same is true for those who lose […]

Weight-loss injections, such as Wegovy and Mounjaro, have transformed how we treat obesity. Around 1.6 million adults in Great Britain have used weight-loss drugs in the past year, with the vast majority of patients buying these drugs privately. The issue with these weight-loss drugs is that, despite their success in shedding weight while patients are taking them, studies report significant weight regain when people come off them. What’s more, the health benefits seen when taking these drugs, […]

A new weight-loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight – Eli Lilly announced on Thursday. The Indiana-based pharmaceutical company in a press statement said that retatrutide, a once-weekly triple hormone receptor agonist, led to an average weight loss of 70.3lb (28.3%) over 80 weeks among participants receiving the 12mg dose, with 45.3% […]

Elaine’s stories explore the boom in new obesity treatments, new drug payment models, the ways companies are affected by FDA changes, and the emerging psychedelics drug sector. She co-writes The Readout newsletter, and co-hosts STAT’s weekly biotech podcast, The Readout Loud. You can reach Elaine on Signal at elaineywchen.70. Eli Lilly reported Thursday that in a late-stage trial, its next-generation obesity drug led to levels of weight loss approaching the effectiveness seen with bariatric surgery, but that […]

A nutritionist said there are lifestyle changes that need to take place in coordination with GLP-1 usage, but a patient who has tried many different diets says it’s worth it. “My journey started around July 2024. I had reached almost 300 pounds,” said Jim Navilio. Navilio said he and his wife decided to try GLP-1 medication. He says he was pre-diabetic and selected Mounjaro. What You Need To Know While GLP-1 curbs appetites, a registered dietician said […]

The “gelatin trick” is going viral on social media for supposedly banishing your appetite and kickstarting weight loss. The idea is simple: Mix gelatin powder with water and chug a glass of the viscous liquid before meals to help you feel full and curb hunger so that you eat less. Proponents of the fad claim it’s an easy, effective strategy to shed pounds. Plus, gelatin has some protein — which we all need more of, according to many […]

You’ve probably heard of Ozempic or Wegovy. These are the injectable drugs that have become household names for weight loss and diabetes. Now, researchers are investigating whether these medications known as GLP-1 agonists or GLP-1 drugs could treat everything from cancer and brain disease to depression, addiction and endometriosis. Some findings are genuinely exciting. Others are being oversold. Here’s what the science actually says. First, how do these drugs work? GLP-1 (glucagon-like peptide-1) is a hormone your […]

Oral semaglutide (Wegovy, Novo Nordisk) tablets for weight loss have been approved by the Medicines and Healthcare products Regulatory Agency (MHRA). In a statement published on 11 June 2026, the MHRA said that the drug — the first oral glucagon-like peptide-1 (GLP-1) available in the UK — can be used in adults with obesity, who have a BMI of 30 or above, or who are overweight with a BMI between 27 and 30 and at least one […]

Popular GLP-1 drugs including Ozempic, Wegovy, Mounjaro, and Zepbound have already transformed the treatment of type 2 diabetes and obesity. Now, new research suggests these medications may also help prevent and treat addiction across a broad range of substances. Researchers at Washington University School of Medicine in St. Louis found that GLP-1 medications were associated with lower risks of developing substance use disorders involving alcohol, nicotine, cannabis, cocaine, opioids, and other substances. The drugs were also linked […]