Share on PinterestA new biweekly GLP-1 injection has been shown to significantly reduce blood sugar in a clinical trial. Image Credit: Hannes P Albert/picture alliance via Getty Images A new GLP-1 medication demonstrated efficacy in reducing blood sugar in people with type 2 diabetes in a phase 2b clinical trial. Bofanglutide is a biweekly (once every 2 weeks) injection compared to once-weekly shots like Ozempic and Wegovy. The new biweekly GLP-1 also led to weight loss and […]

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“I’m now at a point where I’m going to buy even more clothes,” says Hayley Grice, 50, from Shropshire, who has dropped seven sizes after starting on the GLP-1 weight loss jab Mounjaro two years ago. “I’m very happy with my physique right now.” Grice, the financial director of a business she set up with her husband, tried gastric bypass surgery in 2009, but put most of the weight back on, and had been between UK dress […]

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Greta sits in her car and sings to the camera: “Greta, reta, bo, beta, banana, fana, fo, feta, fee, fi, fo, reta, Greta. Trutide.” Cait posts before-and-after pictures—“40 pounds down” and “#jesusloves”—following up with a reading of her favorite psalm. From his bedroom, Gabriel addresses his 462,000 followers about his adventures with low-dose reta—“I think it’s something that everyone should be doing”—and adds a link in his bio to his peptide supplier. These teenagers and twentysomethings are […]

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The study was conducted between 1 November 2022 and 9 April 2025. A total of 128 participants were pre-screened for eligibility, 86 screened for eligibility and 70 (mean age 47.3 years, s.d. ± 10.3; 58 (82.9%) female and 12 (17.1%) male) were randomized: 35 to semaglutide 2.4 mg once weekly plus lifestyle intervention and 35 to placebo plus lifestyle intervention. The trial design and Consolidated Standards of Reporting Trials (CONSORT) diagram is illustrated in Fig. 1. The baseline characteristics of […]

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GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1223–1249 (2020). Article  Google Scholar  Wilding, J. P. H. et al. Once-weekly semaglutide in adults with overweight or obesity. N. Engl. J. Med. 384, 989–1002 (2021). Article  CAS  PubMed  Google Scholar  Gabery, S. et al. Semaglutide lowers body weight in rodents via distributed neural pathways. JCI Insight […]

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{{providers}} Scroll social media long enough and you’ll see promises of microdosing GLP-1s for weight management, inflammation, energy and even longevity. The idea is seductive: Take a tiny dose of a powerful medication to avoid its side effects and lower the cost while still getting its benefits. “Microdosing is not a medical term. It’s a term that has been popularized on social media,” said Amanda Velazquez, MD, director of Obesity Medicine at Cedars-Sinai. “We don’t have any […]

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Guo, H., Yang, J. & Li, L. Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: a model-based meta-analysis of placebo-controlled trials. Obes. Pillars 30, 100162 (2025). Ghusn, W. & Hurtado, M. D. Glucagon-like receptor-1 agonists for obesity: weight loss outcomes, tolerability, side effects, and risks. Obes. Pillars 12, 100127 (2024). Article  PubMed  PubMed Central  Google Scholar  Thomsen, R. W., Mailhac, A. & Pottegård, A. Real-world evidence on the utilization, clinical and comparative effectiveness, and […]

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This book by Dr Ranjan Chatterjee gives some good guideposts to living a Happier Life.He suggests writing down what a Happy life might look like for you and focusing on your values.He says the more micro stress doses(MSD’S) we absorb in a day,we are pushed further to our stress threshold and we need a way to manage this.He cites a study that links self compassion with better physical health and suggests writing a self compassionate letter /note […]

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If you like many struggle with a mindfulness and meditation practice this is the book for you.In the Book Dermot uses a quote “If you dont have time to meditate for 20 minutes a day,then you should meditate for 40 minutes a day”-Zen Proverb The early chapters discuss how you can make a good start to mindful living but fall backwards if you don’t have an intentional practice.In chapter four he says “Mr Miyagi taught me more […]

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